Compared to artificial neuronal networks, cortical circuits can process a remarkably wide range of signal types with varying complexities. In particular, small molecules called neuromodulators are playing a pivotal role in adapting these circuits to various inputs. Interestingly, these modulators are released through a brain-wide and highly complex meta-network. We are interested to understand the working principles of these meta-networks in mice. To do so, we use and develop optogenetic tools and technologies such as photoreceptors engineering, 2P technologies, brain clearing methodology, mini-endoscopy and classical patch-clamp and in-vivo electrophysiology.Compared to artificial neuronal networks, cortical circuits can process a remarkably wide range of signal types with varying complexities. In particular, small molecules called neuromodulators are playing a pivotal role in adapting these circuits to various inputs. Interestingly, these modulators are released through a brain-wide and highly complex meta-network. We are interested to understand the working principles of these meta-networks in mice. To do so, we use and develop optogenetic tools and technologies such as photoreceptors engineering, 2P technologies, brain clearing methodology, mini-endoscopy and classical patch-clamp and in-vivo electrophysiology.

Dr. rer. nat. Matthias Prigge

Plasticity of neuromodulatory networks

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