Why do we feel so bad after a night without sleep? The consequences of sleep deprivation manifest themselves in almost all areas of our daily lives, from cognitive impairment to effects on the cardiovascular system. But what specific processes lead to these drastic consequences of sleep deprivation? We are focused on decoding the exact mechanisms behind the negative consequences of sleep deprivation on our brain and body. We want to understand how lack sleep affects specific neuronal circuits and what role these changes play in memory, attention and cognitive function. Our research is essential to understand the fundamental processes associated with sleep deprivation, and also to subsequently identify potential interventions that could mitigate the negative effects.